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- However, testosterone in physiologic doses might even be beneficial in sufferers with angina , have higher ischemic thresholds and improved quality of life .
- Relationship between endogenous sex hormone levels, lipoproteins and coronary atherosclerosis in males undergoing coronary angiography.
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However, testosterone in physiologic doses may even be helpful in sufferers with angina , have greater ischemic thresholds and improved high quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and increases coronary blood move in men with established coronary artery illness . Therefore, an interplay of endogenous components of the patient’s danger profile as well as the testosterone dosing could additionally be issues of whether adverse events happen. Erythrocytosis has been reported as a potential impact of testosterone, which may be helpful in sufferers with anemia. The best threat of erythrocytosis occurs with injectable forms of testosterone compared with transdermal preparations, particularly in supraphysiologic doses. An increase of up to 44% of the baseline hematocrit has been reported .
Moreover, testosterone has been used within the treatment of decreased muscle mass and bone density as nicely as anemia. The position testosterone might play within the improvement of cardiovascular disease has more and more turn out to be the topic of current interest . Anabolic androgenic steroid use has increased over the past decade, regardless of its potential for antagonistic effects. They continue for use by Olympic stage athletes, and have even spread to highschool stage athletes, noncompetitive bodybuilders and leisure athletes (Sullivan et al 1998; Dhar et al 2007).
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Unfortunately, the information on using high dose anabolic steroids in humans are mainly supplied as case reviews or small research that lack enough control groups. In addition, the info available within the literature doesn’t account for the steroid type or dose, as neither could also be known. Patients also may be taking concomitant stimulants, similar to ephedra, which can confound data and the potential for adverse events. It is likely that the frequency of cardiac events is underreported in the medical literature. Supraphysiologic doses of anabolic-androgenic steroids , which embrace more than 30 pure and synthetic derivatives of testosterone, might cause a large spectrum of scientific sequalae.
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